Giulia Bernardini Selected Research

Homogentisic Acid

3/2024	Alkaptonuria.
1/2022	Homogentisic acid induces autophagy alterations leading to chondroptosis in human chondrocytes: Implications in Alkaptonuria.
10/2020	Homogentisic acid affects human osteoblastic functionality by oxidative stress and alteration of the Wnt/β-catenin signaling pathway.
11/2019	Interactive alkaptonuria database: investigating clinical data to improve patient care in a rare disease.
1/2019	Homogentisic acid induces morphological and mechanical aberration of ochronotic cartilage in alkaptonuria.
11/2017	Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria.
10/2017	Toward a generalized computational workflow for exploiting transient pockets as new targets for small molecule stabilizers: Application to the homogentisate 1,2-dioxygenase mutants at the base of rare disease Alkaptonuria.
7/2017	Cytoskeleton Aberrations in Alkaptonuric Chondrocytes.
5/2017	A new light on Alkaptonuria: A Fourier-transform infrared microscopy (FTIRM) and low energy X-ray fluorescence (LEXRF) microscopy correlative study on a rare disease.
2/2017	Homogentisic acid induces aggregation and fibrillation of amyloidogenic proteins.

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Giulia Bernardini Research Topics

Disease

30	Alkaptonuria 03/2024 - 10/2010
11	Ochronosis 03/2024 - 10/2010
10	Amyloidosis 12/2020 - 01/2011
9	Neoplasms (Cancer) 07/2020 - 06/2006
7	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 10/2010
6	Rare Diseases (Rare Disease) 06/2023 - 11/2012
6	Inflammation (Inflammations) 11/2022 - 12/2016
6	Osteosarcoma (Osteogenic Sarcoma) 07/2020 - 06/2006
5	Infections 01/2017 - 02/2006
2	Neoplasm Metastasis (Metastasis) 07/2020 - 01/2018
2	Disease Progression 11/2019 - 12/2016
2	Joint Diseases (Joint Disease) 05/2017 - 01/2017
2	Tyrosinemias (Tyrosinemia) 01/2017 - 04/2016
2	Rheumatic Diseases (Rheumatism) 12/2016 - 11/2016
2	Metabolic Diseases (Metabolic Disease) 04/2016 - 11/2015
2	Heart Failure 01/2012 - 01/2011
2	Alkaptonuric ochronosis 12/2011 - 10/2010
1	Aortic Aneurysm (Aneurysm, Aortic) 01/2022
1	Aneurysm (Aneurysms) 01/2022
1	Endoleak 01/2022
1	Rupture 01/2022
1	Osteoarthritis 12/2020
1	Knee Injuries (Knee Injury) 12/2020
1	Dysbiosis 05/2020
1	Lesch-Nyhan Syndrome (Choreoathetosis Self Mutilation Hyperuricemia Syndrome) 01/2019
1	Nervous System Diseases (Neurological Disorders) 01/2019
1	Chronic Kidney Failure (Chronic Renal Failure) 01/2019
1	Hyperuricemia 01/2019
1	Renal Insufficiency (Renal Failure) 01/2019
1	Inborn Errors Metabolism (Inborn Errors of Metabolism) 10/2017
1	Systemic Scleroderma (Systemic Sclerosis) 01/2017
1	Arthritis (Polyarthritis) 01/2017
1	Wounds and Injuries (Trauma) 11/2016
1	Amyloid Plaque 01/2014
1	Rheumatoid Arthritis 01/2014
1	Parkinson Disease (Parkinson's Disease) 11/2012
1	Gastritis 02/2011
1	Peptic Ulcer (Peptic Ulcers) 02/2011
1	Stomach Neoplasms (Stomach Cancer) 04/2010

Drug/Important Bio-Agent (IBA)

21	Homogentisic AcidIBA 03/2024 - 10/2010
19	Homogentisate 1,2-Dioxygenase (Homogentisate 1,2 Dioxygenase)IBA 03/2024 - 10/2010
8	EnzymesIBA 01/2022 - 12/2011
8	Proteins (Proteins, Gene)FDA Link 12/2020 - 06/2006
8	Melanins (Melanin)IBA 10/2020 - 10/2010
6	Serum Amyloid A Protein (Serum Amyloid A)IBA 12/2020 - 09/2013
5	Amyloid (Amyloid Fibrils)IBA 02/2017 - 01/2011
4	Biomarkers (Surrogate Marker)IBA 12/2020 - 12/2011
4	Tyrosine (L-Tyrosine)FDA Link 05/2017 - 12/2011
3	nitisinone (Orfadin)FDA Link 11/2022 - 04/2016
3	pyrimidineIBA 06/2014 - 11/2007
3	AntioxidantsIBA 09/2013 - 10/2010
3	AntigensIBA 02/2011 - 10/2007
2	PolymersIBA 01/2019 - 01/2017
2	src-Family KinasesIBA 11/2017 - 05/2008
2	Phenylalanine (L-Phenylalanine)FDA Link 12/2016 - 12/2011
2	CytokinesIBA 01/2014 - 09/2013
2	Congo RedIBA 01/2014 - 11/2012
2	Atrial Natriuretic Factor (ANF)IBA 01/2012 - 01/2011
2	VaccinesIBA 04/2009 - 10/2007
1	CollagenIBA 03/2024
1	purineIBA 06/2023
1	chitotriosidaseIBA 12/2020
1	Advanced Oxidation Protein Products (AOPP)IBA 12/2020
1	Anti-Bacterial Agents (Antibiotics)IBA 05/2020
1	immucillin GIBA 01/2019
1	Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)IBA 01/2019
1	Uric Acid (Urate)IBA 01/2019
1	Xanthine DehydrogenaseIBA 01/2019
1	Allopurinol (Remid)FDA LinkGeneric 01/2019
1	HypoxanthineIBA 01/2019
1	XanthineIBA 01/2019
1	Methylnitronitrosoguanidine (MNNG)IBA 12/2018
1	quinone (benzoquinone)IBA 07/2017
1	Acetic Acid (Vinegar)FDA LinkGeneric 07/2017
1	Virulence Factors (Pathogenicity Factors)IBA 01/2017
1	ProteomeIBA 12/2016
1	Eosine Yellowish-(YS) (Eosin)IBA 11/2016
1	Hematoxylin (Haematoxylon)IBA 11/2016
1	HerbicidesIBA 04/2016
1	DioxygenasesIBA 04/2016
1	Laminin (Merosin)IBA 03/2016
1	Carrier Proteins (Binding Protein)IBA 03/2016
1	Dystroglycans (Dystroglycan)IBA 03/2016
1	LipidsIBA 01/2014
1	Methotrexate (Mexate)FDA LinkGeneric 11/2012
1	AA amyloidosisIBA 11/2012
1	Sulfhydryl Compounds (Thiols)IBA 12/2011
1	Bacterial AntigensIBA 04/2010
1	Bacterial Proteins (Bacterial Protein)IBA 02/2006

Therapy/Procedure

4	Therapeutics 07/2020 - 11/2012
2	Endovascular Aneurysm Repair 01/2022 - 01/2022
2	Drug Therapy (Chemotherapy) 01/2018 - 11/2017
1	Stents 01/2022
1	Precision Medicine 01/2021
1	Kidney Transplantation 01/2019
1	Replacement Arthroplasty 11/2016